Journal Overview
The Global Journal of Medical and Pharmaceutical Sciences (GJMPS) is an international, peer-reviewed, open-access scholarly journal dedicated to publishing high-quality research in the fields of medical, pharmaceutical, and allied health sciences. The journal serves as a global platform for researchers, clinicians, academicians, and healthcare professionals to disseminate innovative scientific findings and contribute to the advancement of healthcare knowledge and practice.
GJMPS aims to promote the exchange of scientific ideas and encourage interdisciplinary research that addresses current challenges in medicine, pharmacy, and biomedical sciences. The journal publishes original research articles, review articles, case reports, and short communications that demonstrate scientific rigor, methodological soundness, and relevance to clinical practice or pharmaceutical development.
The journal follows a rigorous double-blind peer review process to ensure the quality, integrity, and originality of the manuscripts it publishes. Submitted manuscripts are evaluated by qualified experts in the relevant field, and editorial decisions are based on academic merit, research methodology, and contribution to the advancement of scientific knowledge.
GJMPS operates under an open-access publishing model, ensuring that all published articles are freely accessible to researchers, healthcare professionals, and the global scientific community without subscription barriers. This approach promotes the wide dissemination of research findings and enhances the visibility and impact of published work.
The journal adheres to internationally recognized ethical publishing standards and follows the recommendations of the Committee on Publication Ethics (COPE) and the International Committee of Medical Journal Editors (ICMJE). The editorial office maintains strict policies regarding plagiarism prevention, research integrity, authorship transparency, and ethical conduct in research and publication.
By maintaining high editorial standards and supporting ethical scientific communication, the Global Journal of Medical and Pharmaceutical Sciences (GJMPS) seeks to contribute to the advancement of medical and pharmaceutical research and to support the global academic community in improving healthcare outcomes.
All published articles are freely accessible and can be downloaded without restriction through the journal’s official website:
https://globapc.com/
The Global Journal of Medical and Pharmaceutical Sciences (GJMPS) was established in 2022 and is published on a bi-monthly basis, with six issues released each year.
INTRAUTERINE FETAL DEMISE AND ASSOCIATED MATERNAL AND FETAL RISK FACTORS: A CROSS-SECTIONAL STUDY
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)[e-ISSN:2279-0853 &p-ISSN: 2279-0861]Date: 16 March 2026 Paper ID: L524466 Subject: Manuscript Acceptance Letter Dr. BHANU KANTHI MADUGULA, DR MUNIKRISHNA, DR SRUTHI PABOLU Corresponding author: Dr. BHANU KANTHI MADUGULA* We are delighted to inform you that your manuscript titled “INTRAUTERINE FETAL DEMISE AND ASSOCIATED MATERNAL AND FETAL RISK FACTORS: A CROSS-SECTIONAL STUDY”has been accepted for publication in the upcoming issue of the journal IOSR Journal of Dental and Medical Sciences.Details regarding the publication schedule and other necessary steps will be communicated to you shortly. We kindly request you to respond to this acceptance letter at your earliest convenience, confirming your intent to proceed with the publication process.We kindly request that you submit the final version of your manuscript, taking into account any suggestions or revisions recommended by the reviewers, as per the journal's guidelines. RegardsChief-in-EditorIOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
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READ MOREAvulsion Fractures Using a Luggage-Tag FiberWire Configuration
INTRODUCTIONAnterior cruciate ligament tibial avulsion fractures involve separation of the ACL from its tibial insertion while the ligament substance remains intact¹. These injuries are relatively uncommon but are increasingly recognized following sports injuries, road-traffic accidents, and high-energy trauma². The modified Meyers and McKeever classification categorizes these injuries based on the degree of displacement and comminution¹˒³. Type I injuries are minimally displaced and are typically treated conservatively. However, displaced fractures (Types II–IV) usually require surgical fixation to restore normal ACL tension and prevent residual anterior instability⁴. Historically, open reduction and internal fixation were used to treat these injuries. With advances in arthroscopic techniques, minimally invasive fixation methods have largely replaced open surgery due to better visualization of intra-articular structures, reduced soft-tissue trauma, and faster rehabilitation⁵. Several fixation techniques have been described including cannulated screw fixation, suture anchors, and transosseous suture techniques⁶˒⁷. While screw fixation provides rigid compression, it may not be suitable in comminuted fragments and sometimes requires hardware removal⁶. High-strength suture constructs using modern materials such as FiberWire have demonstrated biomechanical strength comparable to screw fixation while avoiding hardware complications⁸. The present study evaluates the outcomes of arthroscopic fixation using a luggage-tag FiberWire configuration with dual tibial tunnels and suture disc fixation in adult patients with displaced ACL tibial avulsion fractures. MATERIALS AND METHODSStudy Design: A prospective case series was conducted at a tertiary orthopaedic center between November 2024 and December 2025. Institutional approval was obtained prior to commencement of the study. Sr No.ParameterValue1Total patients102Mean age233Gender: Male/Female8/24Side: Left/right4/6 Patient Demographics: Inclusion Criteria:Meyers and McKeever Type II–IV fracturesSurgery performed within 3 weeks of injury Exclusion Criteria:Multiligament knee injuryAssociated tibial plateau fracturePrevious knee surgeryChronic avulsion fractures (>6 weeks) Fracture DistributionFracture TypeNumber of patientsType 23Type 35Type 42 Surgical Technique:Patient Positioning and Anesthesia: The procedure is performed under spinal or general anesthesia. A high-thigh pneumatic tourniquet is applied but inflated only after limb exsanguination. The patient is placed supine on a radiolucent operating table with the operative leg in hanging leg position or secured in a leg holder allowing approximately 90° of knee flexion. The contralateral limb is positioned in an abduction stirrup.The entire lower limb is prepared and draped in a sterile manner from mid-thigh to foot. Portal Placement: Standard arthroscopic portals are established:Anterolateral portal: Used as the primary viewing portal and placed just lateral to the patellar tendon at the level of the inferior pole of the patella. Anteromedial portal: Created under direct visualization using a spinal needle to ensure appropriate trajectory toward the tibial eminence. A Passport cannula is introduced through the anteromedial portal to facilitate suture management and prevent soft-tissue bridging. Diagnostic Arthroscopy and Fracture Bed Preparation1. Evacuate hemarthrosis2. Evaluate ACL integrity3. Assess menisci and articular cartilage4. Identify interposed soft tissueSoft-tissue structures such as the intermeniscal ligament or fibrous debris that prevent fragment reduction are removed using a shaver or radiofrequency probe.The fracture crater is gently debrided to expose fresh cancellous bone while preserving the size and morphology of the avulsed fragment. Luggage-Tag FiberWire Configuration: High-strength nonabsorbable FiberWire suture is used.First Stitch: A suture passer is introduced through the Passport cannula and passed through the ACL substance 5–7 mm proximal to the tibial insertion.The free suture end is then passed through its own loop to create a self-cinching luggage-tag configuration. This construct provides:Circumferential ligament captureEven load distributionReduced risk of suture cut-through Second Stitch: A second luggage-tag stitch is placed posteriorly within the ACL substance. This step provides:Rotational stabilityBalanced force distributionSecure capture of both ACL bundles Tibial Tunnel Preparation: An ACL tibial guide is introduced through the anteromedial portal and positioned at the medial margin of the fracture bed. First Tunnel: A 2.7-mm guide pin is drilled from the anteromedial tibial cortex exiting at the medial aspect of the fracture crater. Second Tunnel: The guide is repositioned laterally and a second tunnel is drilled while maintaining a 1-cm bone bridge between tunnels. Preserving the bone bridge is essential to:
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READ MORESulphate and Esmolol for Attenuation of Hemodynamic Responses During Tracheal Extubation Under General Anaesthesia
Aim: To compare the efficacy of intravenous magnesium sulphate and intravenous esmolol in attenuating hemodynamic responses during tracheal extubation in patients undergoing elective surgeries under general anaesthesia. Materials and Methods: This prospective, randomized comparative study was conducted on 120 patients aged 18–60 years, classified as ASA physical status I and II, undergoing elective surgeries under general anaesthesia. Patients were randomly allocated into two groups of 60 each. Group M received intravenous magnesium sulphate, while Group E received intravenous esmolol prior to extubation. Hemodynamic parameters including heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were recorded at baseline, at extubation, and at 1, 3, and 5 minutes post-extubation. Data were statistically analyzed, and a p-value < 0.05 was considered significant. Results: Baseline demographic variables and hemodynamic parameters were comparable between the two groups. Both magnesium sulphate and esmolol attenuated the hemodynamic responses associated with tracheal extubation. However, patients in the magnesium sulphate group demonstrated significantly lower heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure at extubation and during the immediate post-extubation period compared to the esmolol group (p < 0.05). Adverse effects were minimal in both groups, with bradycardia occurring more frequently in the esmolol group.
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READ MOREtest ujudebug test ujudebug test ujudebug test ujudebug test ujudebug
AbstractIn Objective:- The coronary arteries are the principal arterial supply to the myocardium. Variations in their morphology and anatomy have important clinical implications during procedures such as coronary angiography, interventional cardiology procedures and cardiac surgery. The present study was undertaken to document the morphology and anatomical variations of coronary arteries in human cadavers.Methods: This cross-sectional cadaveric study was conducted in department of anatomy of Rajarajeswari medical college and hospital on 64 formalin-fixed adult human cadavers. Detailed dissection was performed to study the number, origin, course, coronary dominance, length, branching pattern and myocardial bridging of coronary arteries. Data was analyzed using descriptive statistical methods and results were expressed as numbers and percentages.Results: Two and three coronary arteries were observed in 56 (87.5%) and 8 (12.5%) cadavers respectively. The right coronary artery was seen to be originating from the right aortic sinus in 64 cadavers (100%) whereas the left coronary artery originated from the left aortic sinus in 64 cadavers (100%). Right coronary dominance was seen in 58 (90.6%) cases and left dominance was observed in 4 (6.3%) cadavers. Co-dominance was present in 6 (9.4%) cadavers. Trifurcation of the left coronary artery was seen in 6 (9.4%) cadavers and Myocardial bridging was found in 8[12.5%] cadavers.Conclusion: The study demonstrated presence of significant morphological variability in the coronary arterial system. Awareness of these anatomical variations is crucial for anatomists as well as cardiac surgeons. This knowledge will reduce procedural complications and improve outcomes during coronary interventions.KeywordsCoronary ArteriesAnatomical VariationCoronary DominanceCadaveric study.INTRODUCTIONThe coronary arteries represent the terminal branches of the ascending aorta and are responsible for the entire arterial supply of the myocardium. Their unique anatomical architecture—arising from the aortic sinuses and coursing over the surface of the heart before penetrating the myocardium—renders them susceptible to a wide spectrum of morphological variations. These variations range from minor differences in ostial position and vessel calibre to significant anomalies in number, origin, course, and termination.1 The clinical importance of coronary arterial anatomy has grown considerably with advances in interventional cardiology and cardiac surgery. Coronary artery anomalies (CAAs) are identified in approximately 0.3–5.6% of patients undergoing coronary angiography, and their accurate delineation is essential before procedures such as percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and transcatheter aortic valve replacement (TAVR).2 Coronary dominance—defined by which artery gives rise to the posterior descending artery (PDA) and the atrioventricular nodal branch—determines the extent of myocardial territory at risk during acute coronary syndromes. Right dominance is the most common pattern globally, though its reported prevalence varies between 80% and 93% across different ethnic populations.3,4 Myocardial bridging (MB), a phenomenon in which a segment of a coronary artery courses through the myocardium rather than the epicardial fat, has been associated with exercise-induced ischaemia, arrhythmias, and even sudden cardiac death. Its prevalence in cadaveric studies is substantially higher than in angiographic series, owing to the compression of intramural vessels that occurs only during systole.5,6 The branching pattern of the left coronary artery (LCA) is particularly variable. While bifurcation into the left anterior descending (LAD) and left circumflex (LCx) arteries is the classic description, trifurcation with the addition of a ramus intermedius (RI) is present in a significant minority and creates an important variant relevant to percutaneous bifurcation treatment.7,8 Despite the clinical significance of these variations, there remains a paucity of systematic cadaveric data from the Indian subcontinent. The majority of large-scale studies have been conducted using coronary computed tomographic angiography (CCTA) or conventional angiography in Western or East Asian populations, and findings may not be fully applicable to Indian patients owing to differences in body habitus, cardiac dimensions, and coronary artery disease risk profiles.9,10 Regional cadaveric anatomical studies are therefore invaluable. Macroscopic dissection allows direct visualisation and measurement of coronary vessels without the limitations imposed by image resolution, cardiac motion artefact, or contrast medium distribution. Several Indian cadaveric studies have reported unique findings, including higher rates of certain branching patterns, that have not been replicated in imaging-based studies from other populations.11,12
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